Jane Irwin studied at Lancaster University and at the Royal Northern College of Music. As a concert singer she has appeared at the BBC Proms, the Edinburgh International and Berlin Festivals and with the Pittsburgh Symphony, Berlin Symphony, Deutsches Symphonie-Orchester Berlin, Orchestre de Paris, Rotterdam Philharmonic, San Francisco Symphony, San Diego Orchestra, Colorado Symphony, Swedish Chamber Orchestra, Zurich Tonhalle, and most of the major British orchestras. She has worked with Myung-Whun Chung, Günther Herbig, Semyon Bychkov, Ivor Bolton, Andrew Davis, Libor Pesek, Donald Runnicles, Antonio Pappano, Sakari Oramo, Sir Mark Elder, Matthias Bamert, Trevor Pinnock, Petr Altrichter, Paul Daniel, Mariss Jansons , Joseph Swensen, Sir Richard Armstrong and Yakov Kreizberg. She has given recitals at the Châtelet, Paris and in London, Edinburgh, Geneva, Aix-en-Provence and Japan.
Jane Irwin has performed at the Royal Opera House, San Francisco Opera, Lyric Opera of Chicago, Deutsche Opera Berlin, Scottish Opera, Opera North and English National Opera.